LINDA

LINDA (Linear Integer programming for Network reconstruction using transcriptomics and Differential splicing data Analysis) as a method that integrates resources of protein-protein and domain-domain interaction, transcription factor targets and differential splicing/transcript analysis to infer splicing-dependent effects on cellular pathways and regulatory networks.

LINDA is being maintained and further developed by DieterichLab. For more details you can check on this publication as well as it’s dedicated Github page.