Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data
Published in Molecular Systems Biology, 2019
A comprehensive logic model of endothelin signalling was constructed using phosphoproteomics data from melanoma cell lines, highlighting the role of specific kinases in Endothelin (EDN)-induced cell migration and supporting the strategic selection of kinase inhibitors for combined treatments with EDN receptor antagonists.
Recommended citation: Schäfer, Alexander, Enio Gjerga, Richard Wd Welford, Imke Renz, Francois Lehembre, Peter Ma Groenen, Julio Saez-Rodriguez, Ruedi Aebersold, and Matthias Gstaiger. 2019. “Elucidating Essential Kinases of Endothelin Signalling by Logic Modelling of Phosphoproteomics Data.” Molecular Systems Biology 15 (8): e8828. https://www.embopress.org/doi/full/10.15252/msb.20198828