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A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.
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About
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portfolio
TACOMA
Transverse Aortic COnstriction Multi-omics Analysis (TACOMA) uncovers pathophysiological cardiac molecular mechanisms
LINDA
Identifying Alternative Splicing effects to Protein interaction Networks
CellNOpt
Creating logic-based models of signal transduction networks using different logic formalisms
PHONEMeS
Modelling large-scale signalling networks from shotgun Mass-Spectrometry
CARNIVAL
Contextualizing large sginalling networks from Gene Expression data
publications
Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data
Published in Molecular Systems Biology, 2019
A comprehensive logic model of endothelin signalling was constructed using phosphoproteomics data from melanoma cell lines, highlighting the role of specific kinases in Endothelin (EDN)-induced cell migration and supporting the strategic selection of kinase inhibitors for combined treatments with EDN receptor antagonists.
Literature and data-driven based inference of signalling interactions using time-course data
Published in IFAC-PapersOnLine, 2019
This paper describes Dynamic-Feeder as a method which combines data-driven inference methods with general literature-based knowledge of proteins interaction networks.
From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL
Published in npj Systems Biology and Applications, 2019
CARNIVAL - a causal network contextualization tool which derives network architectures from gene expression footprints.
Converting networks to predictive logic models from perturbation signalling data with CellNOpt
Published in Bioinformatics, 2020
CellNOpt is a collection of Bioconductor R packages for building logic models from perturbation data and prior knowledge of signalling networks.
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses
Published in Molecular Systems Biology, 2021
COSMOS combines extensive prior knowledge of signaling, metabolic, and gene regulatory networks with computational methods to estimate activities of transcription factors and kinases as well as network‐level causal reasoning.
PHONEMeS: Efficient Modeling of Signaling Networks Derived from Large-Scale Mass Spectrometry Data
Published in Journal of Proteome Research, 2021
PHONEMeS is a method that uses high-content shotgun phosphoproteomic data to build logical network models of signal perturbation flow through the implementation of an efficient Integer Linear Programming (ILP) formulation.
Characterizing alternative splicing effects on protein interaction networks with LINDA
Published in Bioinformatics, 2023
LINDA (Linear Integer programming for Network reconstruction using transcriptomics and Differential splicing data Analysis) is a method that integrates resources of protein–protein and domain–domain interactions, transcription factor targets, and differential splicing/transcript analysis to infer splicing-dependent effects on cellular pathways and regulatory networks.
Adaptive sampling for nanopore direct RNA-sequencing
Published in RNA, 2023
Here we show how Adaptive Sampling for direct RNA sequencing with Oxford-Nanopore technology is feasible considering the specific technical and biological challenges.
talks
Conference Proceeding talk: ISMB/ECCB 2023
Published:
Conference Proceeding talk at The 31st Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology, where I have presented LINDA.
teaching
Proteomics and Integrative Proteomics & Transcriptomics Analysis Techniques
Graduate course, Heidelberg University, 2022
Teaching for the Heidelberg Biosciences International Graduate School (HBIGS). The course focused on the presenting step-by-step analysis of Proteomics data as well as the integrative analysis of Proteomics and Transcriptomics. The lecture was organized over an the EGF-driven protein synthesis case-study date from this paper.
Introduction to Programming with R
Undergraduate course, Heidelberg University, 2023
Course for the undergraduate medical students of Heidelberg University, teaching basic concepts of programming with R. The course was organized around a simple clinical inflammation data-set provided here.
Concepts of Modelling in Biological Systems
Graduate course, Heidelberg University, 2023
Course for the Medical Informatics (Profile Bioinformatics). 2022, 2023. In this course I describe the fundamental principles for doing mathematical modelling of Biological System.